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A few years later, in 2024, researchers in multiple labs were horrified to notice toxic batches of agar for reasons as yet unclear. After they observed a worrying lack of microbial growth (impeding their ability to carry out basic experiments), they switched to different agar suppliers, and their results improved.
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但这种垄断格局，即将被打破，多款在研新药正从作用机制到给药方式，向Vosoritide发起挑战。Ascendis的TransCon-CNP通过包裹技术延长了药物作用时间，实现了周剂给药，目前正处于FDA审批阶段；而BridgeBio的口服药Infigratinib，则从作用机制到用药体验实现全面突破。